CAP - Consortium to Alleviate PTSD - STVHCS Neuroimaging Core

  • Fox, Peter T, (PI)

Research project

Description

Neuroimaging Core
The Neuroimaging Core builds upon a strong foundation developed over the past four years as a STRONG
STAR core. Dr. Fox is currently Director of the STRONG STAR Neuroimaging Core; he will continue in this
role for the STRONG STAR-CAP, being joined by Dr. Krystal as Co-Director. The overall objective of the
Neuroimaging Core is to foster the use of advanced neuroimaging methods in the study of PTSD and related
conditions for the purposes of (1) investigating the underlying pathology (using structural imaging) and
pathophysiology (using functional imaging); (2) assessing and enhancing the diagnostic sensitivity of imaging
methods; (3) investigating the neurophysiology of treatment response (image-based response assessment); and
(4) ensuring comparability of imaging data acquisition and pre-processing between sites. Neuroimaging
methods utilized include structural and functional magnetic resonance imaging (MRI and fMRI), magnetic
resonance spectroscopy (MRS), and position emission tomography (PET). These methods are used in the
context of extensive neurocognitive assessments focused on evaluation of PTSD-related impairments, with
psychometric scores being used as probes for voxel-wise and region-of-interest-based analyses. The
Neuroimaging Core provides standardized core image-acquisition and image-analysis protocols (both structural
and functional), as well as developing project-specific neuroimaging probes. In the ongoing STRONG STAR
Consortium, neuroimaging imaging assessments focused on modeling the system-level effects of PTSD (e.g.,
Ramage et al., 2012) and characterizing the mechanisms of action of cognitive and behavioral therapy. In the
current proposal, emphasis is placed on the mechanisms of action of Prolonged Exposure (PE; project 1), on
pharmacotherapy (ketamine; Project 1) and on insomnia (Project 7). Previously based solely at UTHSCSA's
Research Imaging Institute, the Neuroimaging Core now incorporates a second world-class neuroimaging
facility, i.e., that at Yale. In doing so, the Neuroimaging Core builds upon an ongoing collaborative relationship
with Yale, focused on high-field, small-animal imaging. Image-analysis capabilities at both core components
are outstanding and complementary, with the Research Imaging Institute having exceptional strengths in meta-
analysis and system-level modeling construction and with Yale having exceptional strengths in analysis of
pharmacologic interventions and tracer-based imaging methods.
StatusActive
Effective start/end date9/1/148/31/19

Funding

  • National Institutes of Health
  • National Institutes of Health

Fingerprint

Post-Traumatic Stress Disorders
Neuroimaging
Imaging techniques
Magnetic Resonance Imaging
Image analysis
Neurophysiology
Ketamine
Sleep Initiation and Maintenance Disorders
Cognitive Therapy
Meta-Analysis
Spectrum Analysis
Tomography
Pathology
Image acquisition
Magnetic resonance imaging
Data acquisition
Animals
Spectroscopy

Keywords

  • Medicine(all)